Coagulation factor XIIa inhibitor
The bicyclic peptide FXII618 inhibits coagulation factor XIIa (FXIIa) with a Ki of 22 nM and is >1000-fold selective over other plasma proteases. The bicyclic peptide has thus better inhibitory properties than corn trypsin inhibitor (CTI), a protein that is commonly used as FXIIa inhibitor to block the instrinsic coagulation pathway. Details can be found in the publication Baeriswyl, V., et al., ACS Chem. Biol., 2015 (DOI: 10.1021acschembio.5b00103).